Gates: He saved more lives than any scientist in the 20th century, but Fauci said that he was also unknown in the scientific community.

Originality brings science home.

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In 2016, Bill Gates once commented on a person: He may have saved more lives than any scientist in the 20th century. And Fauci said that this person is also unknown in the scientific community.

Saved so many people but didn’t become famous. This person is Maurice Hilleman.

Maurice Hilleman Image source: nfid.org

Hillemann developed more than 40 kinds of vaccines in his life, and now he invented 8 of the 14 kinds of conventional vaccines for children. He is also the first person in the world who successfully predicted and stopped the pandemic of infectious diseases.

It is estimated that the vaccine developed in Hillemann saves 8 million lives every year. It is no exaggeration to say that he is the guardian of your life and mine. Today, let’s take a look at this hero who does not strive for fame and success.

Hillerman was born on August 40, 1919, the eighth child in his family. Shortly after his birth, his mother and twin sister also passed away. Later, he was adopted to a childless uncle family. Uncle Bichler Mann’s biological father is more enlightened, so he has more opportunities to explore and expand his hobbies.

Childhood Hillemann Image Source: hillemanfilm.com

It is such a child who is interested in Darwin’s theory of evolution. Because of his poor family, he almost didn’t go to college. After graduating from high school, he got a job at J. C. Penney, and he planned to spend his life like this. Fortunately, his eldest brother mediated and helped him get a scholarship from Montana State University. In 1941, he graduated from the school with the first grade.

Then he went to the University of Chicago to study for a doctorate. During his PhD, he studied chlamydia, the pathogen of a common sexually transmitted disease.

In the 1940s, the medical community generally classified chlamydia as a virus. However, Hillemann discovered through research that Chlamydia trachomatis is a special kind of bacteria. Chlamydia trachomatis can only live in cells and is a parasitic bacterium.

Chlamydia trachomatis (brown) Image source: wikipedia

Since it is caused by bacteria, chlamydia can be treated with antibiotics. This is the first city captured by Hillemann for human health.

After obtaining his doctorate, he did not stay in academia, but entered a pharmaceutical company called E.R. Squibb & Sons and began to develop vaccines.

He quickly developed his first vaccine: Japanese encephalitis vaccine. Most encephalitis is caused by Japanese encephalitis virus. After being infected by Japanese encephalitis virus, the patient’s brain swells and the mortality rate is high. During World War II, the Japanese encephalitis vaccine developed by Hillemann was used to immunize the US military.

Japanese encephalitis virus is transmitted by mosquitoes.

In 1949, Hillemann became the chief scientist of respiratory diseases in The Walter Reed Army Institute of Research, when he began to study influenza virus.

During this period, he made several important discoveries about influenza virus. He pointed out to the world for the first time that the spike protein on the surface of influenza virus will change, avoiding the recognition of immune system. Everyone should have heard of spike protein. This year, the COVID-19 vaccine jointly developed by German pharmaceutical company BioNTech and Pfizer was immunized by training human immune system to recognize spike protein on the surface of Covid-19.

Later, biologists called this change of virus antigenic drift, and the major variation was called antigenic shift.

Antigenic transformation often leads to epidemic outbreaks, because few people in the world are immune to the new virus after the virus mutates.

In order to achieve antigenic transformation, the influenza virus that infects people needs two tool animals: birds and pigs. Pigs can be infected by both avian influenza virus and human influenza virus. Therefore, the two viruses can communicate in pigs to form a new and stronger influenza virus.

Hillemann’s discovery explains why the flu vaccine developed by the US military usually fails in the second year, and also helps him save millions of lives.

On April 17th, 1957, The New York Times reported the news of a large-scale influenza outbreak in Hongkong. Many Americans don’t think this is a disaster in a foreign country, and it has nothing to do with themselves. But Hillemann was keenly aware that the news was not simple.

During the Asian flu in July 1968, patients waiting for treatment in a clinic in Hong Kong. Image source: SCMP

The day after reading this report, he sent a telegram to an army medical general laboratory in Zama, Japan, and obtained the saliva of an infected American soldier.

After studying the patient’s saliva, Hillemann found that only a small group of old people who had experienced the "Russian influenza" pandemics in 1889 and 1890 had immunity, while younger people had no resistance to the new influenza virus.

Hillemann realized that the global influenza pandemic had arrived, and began to actively promote the development of influenza vaccine before the start of school in autumn.

In September 1957, an epidemic named the Asian flu entered the United States. However, at that time, the United States had produced and distributed 40 million doses of influenza vaccine, and the research and development time of the vaccine was only four months.

This is the attendance of a primary school in Tokyo when the Asian flu broke out at that time.

In the end, this virus (Type A2) called "Asian Influenza" caused about 70,000 deaths in the United States. But in 1957-1958, the virus caused about 2 million deaths worldwide.

Leonard Burney, then director of the US Department of Health, said that without this vaccine, millions of people in the United States would have died of the flu.

In this way, Hillemann became the first person in history to accurately predict the pandemic. Because of this incident, Hillemann was awarded the Distinguished Service Medal by the US military.

At the end of 1957, Hillemann began to work for Merck Pharmaceuticals and stayed there until he retired. At Merck, he developed vaccines against chickenpox, hepatitis A, hepatitis B, streptococcus pneumoniae, meningococcus, measles, mumps and rubella.

Mumps often leads to deafness. Image source: wikipedia

Hillemann was also the first person to integrate antiviral vaccines. With the triple vaccine against measles, mumps and rubella, children can gain immunity to measles, mumps and rubella only once.

Mumps vaccine has reduced the number of patients in the United States from 200,000 to 200 every year. The World Health Organization estimates that measles vaccine alone prevented 20.3 million deaths worldwide from 2000 to 2015.

There is another interesting story when it comes to the measles-mumps triple vaccine.

In fact, the virus used to make mumps vaccine was extracted from his adopted daughter Jeryl Lynn. Until now, the virus strain from his daughter is still being used to make mumps vaccine, and this virus strain is also named Jeryl Lynn strain.

Hillemann’s last invention-hepatitis B vaccine also made him the first person to fight cancer-liver cancer with a vaccine.

Hepatitis B virus is a major pathogen of liver cancer, the third largest cancer in the world. According to Baruch Blumberg, the Nobel Prize winner in 1976, there are about 375 million people in the world who are carriers of hepatitis B virus, and they are all at risk of liver cancer.

In order to develop hepatitis B vaccine, Hillemann did a very dangerous thing-purified hepatitis B surface antigen (HBsAg) from the blood of patients with hepatitis B and made hepatitis B vaccine.

Schematic diagram of hepatitis B surface antigen (purple)

There are two reasons why this matter is dangerous: First, in the process of research, hepatitis B virus may infect researchers.

Secondly, who wants to try a vaccine made of patient plasma at the cost of his life? After all, the protein of hepatitis B surface antigen is what hepatitis B virus does in human body to avoid the attack of immune system. Many people without medical background are afraid that they may be infected with hepatitis B after being injected with this protein.

In order to prove the effectiveness and safety of the vaccine, Hillemann personally went into battle and injected hepatitis B vaccine under the watchful eye of everyone.

Hillemann was vaccinated with the first generation of hepatitis B vaccine. Image source: vaccine makers project

However, because a new deadly disease, AIDS, appeared in the 1980s, many people were afraid that the hepatitis B vaccine purified from plasma might also carry the pathogen of AIDS, so the first generation of hepatitis B vaccine was in trouble.

However, Hillemann’s team soon found a way to make hepatitis B vaccine without human plasma. In 1986, they used gene technology to successfully make yeast produce HBsAg.

This vaccine is now used in 150 countries around the world. By 2003, the number of young hepatitis B patients in the United States had dropped by 95% compared with before the emergence of vaccines. Hepatitis B vaccine may be the medical product that saved the most people in the 20th century.

Hillemann believes that hepatitis B vaccine is the most important job in his life. Thomas Studds, a pioneer of liver transplantation, praised hepatitis B vaccine as "one of the greatest contributions to medicine in the 20th century. Hillemann has removed the biggest obstacle in the field of organ transplantation. "

After retirement, Hillemann became a consultant of the World Health Organization. In 1988, President Reagan awarded him the National Medal of Science award, the highest honor in American science.

Image source: the Hilleman Family

Although many people’s lives depend on him, few people outside the circle know his name and he didn’t win the Nobel Prize.

Robert Gallo, the co-discoverer of HIV virus, the pathogen of AIDS, once said: "If you want to name a person who has made great contributions to human health, but has not received due recognition, this person is Hillemann."

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, even said: "Even in the scientific community, few people know how much Morris has contributed. I recently asked my postdoctoral fellow if he knew who developed measles, mumps, rubella, hepatitis B and chickenpox vaccines. They said they didn’t know. "

Hillemann didn’t go out of the circle because of his low profile. Hillemann didn’t sign a paper to prove the effectiveness of hepatitis B vaccine, nor did he name any vaccine with his own name.

Hillemann seems to be the embodiment of human immune system. A healthy human body can’t benefit from the immune system, but TA has been silently protecting you in an invisible place.

Hillemann saved the most people in the 20th century, and some people’s hard disks saved the most people in the 21st century.

Untagged picture source network.

Reference materials are stored in graphite:

https://shimo.im/docs/cxWWVjVhRkTQ3YJc/

Original title: "Gates: He saved more lives than any scientist in the 20th century, but Fauci said he was unknown in the scientific community."

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Expert interview: Old viruses frequently change their faces. Traditional antivirus is in a hurry.

  New anti-virus technology for active defense


  The opening and closing ceremonies of the Beijing Olympic Games and Paralympics are the focus of the world’s attention. Assuming that the computer information of the general director Zhang Yimou is stolen and attacked by hackers, not only will the Olympic plan be leaked, but even the opening and closing ceremonies will not be able to proceed normally …


  In the US presidential election, Obama was most worried about the theft of his core computer and the attack on the network. He summed up his victory and the victory of the network.


  Network security has a bearing on the people’s livelihood. Faced with more than 1,000 new viruses appearing every hour in the world, traditional anti-virus software is increasingly lagging behind, and active anti-virus technology emerges as the times require.


  According to the 2008 National Survey Report on Information Network Security and Computer Virus Epidemic released by the Ministry of Public Security recently, among the types of network security incidents, computer viruses, worms and Trojan horses are still very prominent, accounting for 72%. Another new security risk "passive leak" is eroding the computer network.



  Liu Xu, a famous anti-virus expert and leader of the research group of "Real-time protection technology based on independent analysis and judgment of program behavior" of the National 863 Program.


  What causes the increase of "passive disclosure", and how can users avoid being victims of Trojan virus or targets of "spy" programs? The reporter interviewed Liu Xu, a famous anti-virus expert and the leader of the research group of "Real-time protection technology based on autonomous analysis and judgment of program behavior" of the National 863 Program.


  Hackers wholesale a "broiler" in 0.1 yuan.


  Zombies attack other people’s computers in groups


  Users unconsciously passively leak secrets.


  Liu Xu said that in the industry, computers controlled by hackers are called "broilers", and any computer may become a "broiler". For hackers, "broiler" has no secrets, and all information files can be easily adjusted. Such a "broiler" is now sold online only in 0.1 yuan. Because of its low price, "broiler" is generally sold in tens of thousands of wholesale units. Recently, the use of "Microsoft black screen genuine verification" to spread the variant gray pigeon new virus is to make the user’s computer a remotely controlled "broiler".


  There are even more terrible "zombies", that is, computers controlled by "zombie" viruses. These computers are aggressive, and the "zombie" computers controlled by hackers form a network, which will attack other people’s computers and important websites. "Zombies" are mostly overseas hacker networks, mainly stealing trade secrets and threatening the security of national information networks.


  Liu Xu said that the purpose of writing and making viruses has changed from "harming others without benefiting themselves" to profit-seeking attacks, such as stealing information; The computer poisoning rate also rose from 73% in 2001 to 91.47% last year. At present, viruses have the latest features such as instrumentalization and automatic generation, and at the same time, they have the characteristics of concealment, anti-killing and pertinence. Unknown viruses and new viruses make users hard to prevent. In the past two years, "online thieves", "panda burning incense", "dove", "QQ Trojan" and "zombie Trojan" have invaded users’ computers and stolen password accounts, personal privacy, business secrets, network property and even state secrets, which are typical examples. If we don’t take precautions against these Trojans and spy viruses, it will easily cause users to passively disclose information unconsciously.


  Traditional antivirus only looks for a piece of program code.


  There is nothing I can do about makeup makeovers.


  Almost all computers are equipped with anti-virus software, but why are users repeatedly attacked and even passively leaked information? Liu Xu said that the traditional anti-virus software was an effective tool in the past when the number of viruses was small and the spread speed was not fast. However, today, with the wide application of the Internet and the subversive changes in the global virus characteristics, it is obviously inadequate.


  Liu Xu analyzed the principle of traditional antivirus software. For example, traditional anti-virus software kills viruses, just like low-level security guards catch thieves, relying entirely on local characteristics. If you catch a thief in red today, you think that everyone in red is a thief, and if you catch a thief in yellow tomorrow, you think that the thief in yellow is also a thief. When a virus is found, one or several program codes are found, which is the virus feature code. Once similar or identical codes are found, it is considered as a virus. Traditional anti-virus software adopts the eigenvalue scanning technology: the idea of "virus appearance ―― user submission ―― manual analysis by manufacturers ―― software upgrade". The prevention of virus always lags behind the emergence of virus, and generally it can only kill the virus found by manufacturers, but it is helpless for new viruses or those that have undergone "cosmetic" transformation.


  At present, viruses have been automated and industrialized, and anti-virus manufacturers are still adopting backward ideas of manual analysis, which is bound to fail to prevent unknown viruses and new viruses. Realizing the transformation of anti-virus technology from passive anti-virus after the event to active defense is not only the common topic and new competition focus of the global anti-virus industry, but also the urgent demand of computer users.


  Micro-point active defense software of 863 project


  Ensure the network security of the opening and closing ceremonies of the Olympic Games


  Liu Xu said that at present, most anti-virus software claims to have active defense function, but active defense is a real-time protection technology based on independent analysis and judgment of program behavior, which must have three basic characteristics: independent identification of unknown viruses and new viruses, clear reporting and automatic removal. This is the touchstone to distinguish between true and false active defense, especially "clear reporting" of unknown viruses and new viruses, which most anti-virus software can’t do.


  In addition, some traditional anti-virus software does not explicitly report whether there is a virus, but uses some languages that ordinary users can’t read, such as: "A program is setting a global hook for your computer, is it allowed?" and "A program is loading a driver, please choose", so that users can judge for themselves, and it is difficult for non-computer professionals to choose.


  The national 863 project-micro-point active defense software is the first active defense software in the world. By using the simulated anti-virus expert and its virus determination mechanism, it has achieved the breakthrough of five core technologies, such as "dynamic simulation of anti-virus expert system, automatic and accurate determination of new viruses, simultaneous monitoring of program behavior, automatic extraction of feature values to achieve multiple protections, and visual display of monitoring information". After nearly a million kinds of viruses have been tested, the effective rate of preventing and killing unknown viruses and new viruses is over 99%.


  Since the opening and closing ceremonies of the Beijing Olympic Games, the operation center adopted the national 863 project-micro-point active defense software, which successfully prevented the attacks and intrusions of hackers and various new and old viruses, and the network information system of the operation center never leaked information, which indicates that China’s anti-virus technology has successfully withstood the major test of the Beijing Olympic Games and Paralympic Games.


  Don’t go to unhealthy websites to avoid being poisoned.


  Rejecting unknown mail is best for special plane.


  Copying files between computers without USB flash drive


  Liu Xu pointed out that users should have a conscious awareness of information security. First of all, we should develop good online habits. Some unhealthy websites are often an important reason for users’ virus infection.


  Secondly, it is not only a way to infect and spread the virus, but also an important reason for the passive disclosure of information caused by virus attacks and hacker intrusions. In practical work, especially for users with high requirements for information security, we should try our best to put an end to copying files back and forth between different users with USB flash drives, and we should also strengthen the protection of users’ own mail security and refuse unknown mail. At the same time, the conditions should be dedicated to the special plane.


  Third, adopt safe and reliable anti-virus tools. More and more examples have proved that anti-virus software itself is vulnerable to attack. Therefore, we should not only use non-genuine software with caution, but also carefully choose anti-virus tools. It is a reliable choice to adopt anti-virus tools with real active defense technology. (Reporter Li Dongmei)

Editor: Wang Jiaolong

Joint venture car companies that were eliminated from China without making progress.

Hainan (hard development was eventually abandoned by foreign parties)

Home of the car

  In the late 1980s, after the establishment of Hainan Province and Hainan Special Economic Zone, the local government hoped to develop its own automobile industry in this new hot spot. Hainan Automobile Stamping Factory, which has experience in automobile parts production, was supported by the government and bought a low-cost vehicle production line from the turbulent Philippines at that time. However, Hainan Factory, which was not supported by Ford of the United States, never had any models to produce. At that time, Japan’s economy declined sharply. In order to seek new profit points, Hainan Automobile Factory and Mazda hit it off, and the two sides decided to jointly produce Mazda models in Hainan. In October, 1990, the first Mazda 929 in Hainan Automobile Stamping Factory was successfully trial-produced.

Home of the car

  In 1991, Hainan Stamping Parts Factory began to assemble Mazda 929 wagon (HMC6470) with small quantities of imported parts. However, due to the lack of necessary technical support and relevant production experience, the assembly technology of this wagon is far from that of overseas models. In August of the same year, Hainan Automobile Stamping Factory, Japan Mazda Automobile Co., Ltd. and Japan Itochu Corporation initialled the contract, with Japan holding 25% of the shares. In February 1992, Hainan Mazda Automobile Co., Ltd. was established by Hainan Automobile Factory and Japan Mazda Automobile Company, and HMC6470 station wagon was officially put on the market. At the beginning of the joint venture, China put forward the demand for localization, but due to the lack of scientific and rigorous localization work, although the localization rate of HMC6470 has reached 70%, it soon showed common quality problems after it was put on the market. In 1991 and 1992, Hainan Stamping Parts Factory produced 2.06 million stamping parts for Shanghai and realized a profit of 12 million yuan, which eased the survival crisis of Hainan Mazda at that time.

Home of the car

  The fifth-generation Mazda 929, the flagship model launched by Mazda in 1991, was all the rage in China. The car was imported into China, and its frameless door and slender overall shape were unforgettable. What is unknown, however, is that Hainan Automobile Factory once imported parts of Mazda 929 in small batches for assembly production, and 26 cars were assembled and produced in the same way as Mazda 929 at the same time. However, the output of 626 and 929 produced in Hainan at that time was extremely low, and the logo of Hainan Mazda was not attached to the car body, which made these two cars used to be imported by some dealers for sale.

Home of the car

  At that time, the central government hoped that Hainan Automobile Factory and Guangdong Samsung Group would jointly set up a commercial vehicle joint venture with China as the main body. At first, the foreign investor was selected as an American company, and then the government changed the foreign partner to a German automobile company. Mercedes-Benz put forward the condition that Hainan Automobile Factory could not jointly produce cars with Japanese Mazda. Since then, the project negotiations have lasted for three years, and finally Mercedes-Benz decided to abandon the joint venture project, and the cooperation process between Hainan Automobile Factory and Japan Mazda was also interrupted during the negotiations. In 1993, Hainan Automobile Factory successively assembled and produced Mazda E2000(HMC6440) and Mazda (HMC6450) in the form of CKD.

Home of the car

  In 1994, Hainan Mazda launched the Hainan Mazda 323(HMC6430) based on the sixth generation 23. This car is equipped with a 1.3L four-cylinder with a maximum horsepower of 73 HP. Compared with HMC6470 station wagon, the assembly technology and vehicle quality of Hainan Mazda 323 have made a qualitative leap. Although the joint venture company has been established, Hainan Automobile Factory has not obtained the automobile production license issued by the state, and the cars it produces can only pass through Hainan Province. Even though many Mazda models made in Hainan can be seen all over the country at that time, this sales volume is a drop in the bucket for a car company. Hainan Mazda was on the verge of bankruptcy in 1997. In order to obtain the qualification of automobile production, the Hainan provincial government agreed to be affiliated with a large state-owned automobile enterprise. In November, 1997, the Group and Hainan Provincial Government formally signed an agreement, and the two sides realized asset reorganization by means of free transfer of state-owned assets.

Home of the car

  In January 1998, Hainan Mazda officially joined FAW Group, and FAW Hainan Automobile Co., Ltd. was put into operation. The models produced by this company can finally be sold in the national market. However, Hainan Mazda, which belongs to FAW Group, has not received financial and technical support from FAW, but only obtained the qualification to produce cars. In March 1999, HMC6470 station wagon produced by Hainan Automobile was approved for sale in the whole country. Two months later, Hainan Automobile introduced HMC6470 station wagon with domestic 4Y(491) engine, and its localization rate has reached 85%. In October of the same year, Hainan Automobile launched Mazda 323 car named CA7160, which was equipped with a 1.6-liter carburetor engine. Since more than 90% of the parts need to be imported, Hainan Automobile finally gave up MPV.

Home of the car

  Although there has been a few years’ gap with Japan’s Mazda, with the gradual recovery of Japan’s economy, Mazda also urgently needs to seek partners after seeing the huge business opportunities in China market. Hainan Auto once again hit it off with Mazda. However, due to its previous investment in China, the cautious Japanese decided to adopt technical cooperation this time. In May 2001, Mazda’s compact MPV(Premacy) was officially launched in FAW Hainan. Due to the relative shortage of domestic MPV models at that time, Prima produced by FAW Hainan Mazda quickly occupied the dominant position of domestic compact MPV once it was launched. By the end of 2001, Hainan Mazda Prima had sold more than 10,000 vehicles.

Home of the car

  The success of Prima increased the confidence of FAW Hainan Mazda in introducing new models. In July 2002, Hainan Mazda introduced the eighth generation Mazda 323, which was born in 1998, into China, and the domestic Mazda 323 was named as. Hainan Mazda initially did not give Familia the 1.6-liter and 2.0-liter engines used in overseas models, but chose the same 1.8-liter naturally aspirated engine and two gearboxes as Prima, which effectively controlled the manufacturing cost of Familia. Familia was quickly recognized by consumers after its launch. Since then, the listed products and Familia have been called the "new three" of China automobile market.

Home of the car

  In August, 2003, Hainan Automobile established the Automobile R&D Co., Ltd. in Shanghai. The hot sales of Prima and Familia made Hainan Mazda become the mainstream automobile production at that time in the following years, and also made Japanese Mazda see the great potential of China automobile market, which made it have greater ambition to expand China automobile market. As the saying goes, it is good to enjoy the cool under a big tree. At this time, Mazda is no longer satisfied with the profits brought by technical cooperation with Hainan Mazda. Since then, Mazda has directly thrown the olive branch to the stronger FAW Group. In March 2005, FAW Group, FAW Car Co., Ltd. and Japanese Mazda Automobile Co., Ltd. jointly established FAW Mazda Automobile Sales Co., Ltd., and mazda 6 was put into production in FAW Mazda soon.

Home of the car

  After mazda 6 was "won" by FAW, the automobile group, Ford Motor Company and Mazda Motor Co., Ltd. jointly established Changan Ford Mazda Automobile Co., Ltd. in February 2006, and Familia’s successor Mazda 3 was officially put into production shortly after the establishment of the new company. Hainan Mazda once again encountered the embarrassing situation that there were no new models to introduce. After passing by two new models, Hainan Mazda had no choice but to continue to support itself in the increasingly competitive domestic market with Prima and Familia. It is in this embarrassing situation that Hainan Automobile turned from a joint venture to a road of building its own brand, and Haima Automobile was established during this period. Although many models launched later were still based on the original Mazda models, the logo of "Hainan Mazda" never appeared on these models again.


Changhe (started smoothly but failed to maintain its advantage, and the model was delayed and forgotten by the market)

Home of the car

  In February, 1984, Chang ‘an Factory and Suzuki Company of Japan formally signed a technical and trade cooperation agreement to cooperate in mini-car and engine projects. On November 15th of the same year, the first batch of Changan brand SC112 minivans and SC110 minivans were officially rolled off the assembly line, which also marked the official transformation of Changan Factory from a military enterprise to a civilian vehicle manufacturer. Thanks to the domestic demand for low-end passenger and freight vehicles at that time, Changan brand mini-series vehicles were quickly recognized by the market once they were launched. At the same time, many automobile manufacturers in China, such as Changhe Aircraft Factory and Harbin Aircraft Factory, successively obtained technical support from Suzuki Company or produced Suzuki Carry as the prototype by self-imitation. For a time, various domestic minivans and minivans were popular all over the country.

Home of the car

  Following the joint venture between Changan Automobile Factory and Suzuki of Japan in 1993, Jiangxi Changhe Automobile Co., Ltd. and Jiangxi Changhe Aviation Industry Co., Ltd., which had experience in producing Suzuki Carry mini-cars, jointly established Jiangxi Changhe Suzuki Automobile Co., Ltd. with Suzuki Co., Ltd. and Okaya Steel Co., Ltd. in June 1995. The Chinese side holds 51% of the shares and the Japanese side holds 49%. Changhe Suzuki continues its early business model of producing mini-cars, and its main products cover mini-vans, economical cars and engines. Changan Suzuki will be the first model to be introduced into China. Changhe Suzuki failed to launch its first model after its establishment, and finally they set their sights on Suzuki’s+in 1997.

Home of the car

  Changhe Suzuki finally made Wagon R+ domestically in 2001. This Suzuki car was originally equipped with a 1.0L engine. In 2004, it launched a 69-horsepower 1.2L engine with a maximum of 95N·m and a 5-speed. Low price and spacious interior space are sought after by working-class consumers and some individual merchants. In 2005, Changhe Suzuki replaced the Big Dipper with a 1.4L engine with a maximum power of 95 HP. Over the past few years, Changhe Suzuki has only made some minor configuration adjustments to the Big Dipper, and its appearance has always been the same. Although the replacement model of Wagon R+ was launched in overseas markets in 2000, Changhe Suzuki never considered this matter, and the Big Dipper has been continuously "upgraded" and sold.

Home of the car

  In November, 2005, Changhe Suzuki introduced a domestically produced model that is extremely important to it. The prototype of this car is Liana introduced by Suzuki in overseas markets in 2001, and Suzuki introduced a domestically produced modified model of Liana listed overseas in 2004. Although it was launched one year later than the prototype, it is a very timely new product for Changhe Suzuki compared with the old Big Dipper. The Liana version was first launched, with four models priced at 102.8 to 117.8 thousand yuan, equipped with a 1.6L engine with a maximum power of 95 horsepower, equipped with 5-speed manual and 4-speed. In March, 2006, Changhe Suzuki launched five more versions of Liana, but compared with Changan Suzuki and other models that were popular at that time, the sales of Liana could not satisfy Changhe Suzuki.

Home of the car

  In order to enhance the competitiveness of products, Changhe Suzuki upgraded the power system of Liana, and the maximum power of the 1.6L VVT engine was increased to 109HP. The original Changhe automobile was famous for its production, and Changhe Suzuki launched a high-profile one in May 2007. This car is equipped with a 95 HP 1.4L four-cylinder engine. In addition to the standard 5-speed manual transmission, Changhe Suzuki even introduced a 4-speed automatic transmission, which was definitely an extremely bold decision in the domestic micro-market at that time. In addition, Changhe Suzuki has even launched a system of Langdi. Although Langdi is very competitive in the micro-market, its sales volume is not ideal due to the over-supply of micro-surface, which is mainly commercial. After several years of hard work, it finally withdrew from the market.

Home of the car

  At the end of 2009, Changhe Suzuki was planned to be a subsidiary of Changan Automobile Group. Changhe Suzuki, which was already on the edge of the market, gradually stopped using Suzuki logo in 2011 and replaced it with a brand-new Changhe Suzuki "Three Rings" logo. In November, 2011, Changhe Suzuki introduced the last Suzuki model made in China, and officially met with consumers based on the Suzuki Splash launched by Suzuki in overseas markets in 2008. Suzuki Splash in overseas markets is equipped with 1.0L three-cylinder and 1.2L four-cylinder with code K10B and K12B, and a 1.3L four-cylinder, while Paixi in China uses 99HP and 101HP 1.4L four-cylinder engines with code K14B-C and K14B-G (with VVT technology).

Home of the car

  The positioning of Changhe Suzuki Paixi is similar to that of Changan Suzuki Swift, but it may be due to the fact that Suzuki logo is not used, and the market recognition of Changhe Suzuki itself is not enough, resulting in the highest monthly sales of Paixi after listing, which is quickly forgotten by consumers. Due to the poor management of Changhe Suzuki, there was no energy and funds to introduce new models to revitalize the enterprise after Paixi stopped production. Changhe Suzuki was finally reorganized by BAIC Group in November 2013. Since then, the restructured Suzuki has no longer received technical support from Suzuki, and the models produced since then have also been developed on the basis of the original Big Dipper and Liana, and Changhe Suzuki has since withdrawn from the China market.


Conclusion:

  Looking back at these car companies that have withdrawn from China, many car companies have the advantages of favorable weather, geographical location and human relations. After several years of smooth development, the situation has turned sharply. This is more because of overconfidence, whether it is for our own products or for the market. However, the competition in the domestic automobile market has always been cruel. Once you have the idea of living on your laurels, you are doomed to be abandoned by consumers. Looking back at these car companies that have withdrawn from China, most of them are because of this. Nowadays, the competition in the domestic automobile market is more intense. If you want to gain a foothold in the market, you must come up with excellent products and quality services, otherwise it will be a matter of time before you "leave" … (Photo/Text Li Haopeng)

Home of the car

Click here for details.

BMW pure electric 5 series upgrade again! Dual-motor four-wheel drive+large battery, sold from 485,900.

On November 15th, BMW i5 eDrive40L and xDrive50L were listed at Guangzhou Auto Show, with official prices of 485,900 yuan and 539,900 yuan respectively. The eDrive40L is 46,000 more expensive than the eDrive35L entry-level version on sale. The two new cars are equipped with high-power single motor and front and rear double motors, respectively, which match the larger capacity. The CLTC cruising range is 713km and 651km.

The two new models of i5 are equipped with 12.3-inch +14.9-inch screen, iDrive8.5 car system and Qualcomm Snapdragon 8155P chip, and the high-equipped models are equipped with the integrated module of V2X car and Lu Yun. The new car comes standard with panoramic star-track canopy, front seat heating/ventilation, Harman Kardon audio and so on.

The i5 eDrive 40L can be regarded as a long-life version of rear drive, equipped with a high-power rear single motor, with 6.7s acceleration at zero speed, 96.96kWh matching and 713km battery life under CLTC working conditions. The xDrive 50L is equipped with front and rear dual motors, with maximum power of 190/250kW and acceleration of 4.2s at zero speed, making it the fastest domestic vehicle.

People who swim for a long time will have these four major changes in their bodies. How many do you know?

Swimming has become a standard sport in summer, and lying in a cold pool in summer is a great pleasure in summer! In addition to the comfort of cooling, swimming has several unknown benefits. Let’s take you to know about the benefits of swimming and related taboos today ~

Four benefits of swimming:

Step 1 lose weight

Swimming is one of the most effective ways to lose weight. Experts’ experiments show that the heat consumed by staying at 12 degrees Celsius for 4 minutes can only be consumed in 1 hour on land at the same temperature. The reason for such a big difference is that the density and heat transfer of water are greater than that of air, so regular exercise in water can gradually consume more fat and shape a more perfect posture.

2. It is beneficial to the recovery of chronic respiratory diseases.

Swimming can exercise the respiratory muscles such as pectoral muscle, diaphragm muscle and intercostal muscle, thus improving the ventilation function of the lungs and improving the efficiency of breathing. Proper swimming exercise is beneficial to the rehabilitation of patients with chronic respiratory diseases.

Step 3 strengthen your heart

As a horizontal exercise, swimming can not only make all parts of the body bear the same gravity, but also balance blood circulation and strengthen the heart.

Step 4 soothe joints

Different types of swimming movements can exercise the joints of the body. In addition, because the water has buoyancy when swimming, the legs are free from supporting the weight, and the main joints of the thighs can be relaxed and relieved.

Although swimming is good,But there are still a few points to pay attention to..

1. It is not advisable to swim for a long time.

The swimming duration should not exceed 1.5-2 hours. Because people stay in the water for a period of time, the blood flow on the body surface expands, and the skin turns from cold to warm. However, once they stay in the water for too long, the skin will gradually appear goose bumps and chills, which will have a certain impact on health.

2. It is not advisable to eat immediately after swimming.

Because swimming consumes a lot of fat and calories, there will be some hunger after swimming. However, eating immediately after swimming will increase the burden on the stomach and intestines, which will easily lead to gastrointestinal diseases for a long time. Therefore, you should rest for 1 hour before eating.

3. Patients with otitis media, dermatosis and acute conjunctivitis should avoid swimming.

There are a lot of bacteria in the swimming pool. If people with the above diseases swim again, it will not only make the original condition worse, but even spread the disease bacteria in the swimming pool, causing infection to others.

4. Pay attention to cleaning after swimming.

After swimming, you should take a bath or dry your body with a towel immediately, then drop Chlorella or boric acid eye drops on your glasses and clean up nasal secretions. If there is water in the ear, you should use "jumping on the same side" to discharge the water, so as to avoid the eardrum injury caused by hand digging.